Hypofractionated versus conventional radiotherapy in patients with low/intermediate-risk localized prostate cancer: review of rectal and urinary toxicity
WCRJ 2016; 3 (3) : e751
Topic: Genitourinary cancer
Category: Review
Abstract
Purpose: This review has the purpose of comparing radiation toxicity in patients with localized prostate cancer treated with conventional fractionation, hypofractionated and extreme hypofractionated to analyze the impact of techniques and technological innovation on the management of prostate cancer.
Materials and Methods: We searched PubMed trials that examined acute and late urinary/gastrointestinal toxicity in patients with low/intermediate risk localized prostate cancer treated with radiotherapy. We grouped studies into 5 groups, analyzed the acute and chronic toxicity detected, and calculated mean of the percentage for toxicity ≥ G2 and odds ratio (OR) in the different groups.
Results: Regarding the gastrointestinal and genitourinary acute/late toxicity, Intensity Modulated Radiation Therapy (IMRT) hypofractionated technique is advantageous of 3DCRT hypofractionated and IMRT with conventional fractionation. Stereotactic Body Radiation Therapy (SBRT) is advantageous of IMRT hypofractionated, only for acute and late gastrointestinal and acute genitourinary toxicity.
Conclusions: This preliminary analysis shows that hypofractionated scheme, especially IMRT, provides an increased tolerance of treatment. SBRT with Cyberknife system, represent in selected cases, a future challenge.
Materials and Methods: We searched PubMed trials that examined acute and late urinary/gastrointestinal toxicity in patients with low/intermediate risk localized prostate cancer treated with radiotherapy. We grouped studies into 5 groups, analyzed the acute and chronic toxicity detected, and calculated mean of the percentage for toxicity ≥ G2 and odds ratio (OR) in the different groups.
Results: Regarding the gastrointestinal and genitourinary acute/late toxicity, Intensity Modulated Radiation Therapy (IMRT) hypofractionated technique is advantageous of 3DCRT hypofractionated and IMRT with conventional fractionation. Stereotactic Body Radiation Therapy (SBRT) is advantageous of IMRT hypofractionated, only for acute and late gastrointestinal and acute genitourinary toxicity.
Conclusions: This preliminary analysis shows that hypofractionated scheme, especially IMRT, provides an increased tolerance of treatment. SBRT with Cyberknife system, represent in selected cases, a future challenge.
To cite this article
Hypofractionated versus conventional radiotherapy in patients with low/intermediate-risk localized prostate cancer: review of rectal and urinary toxicity
WCRJ 2016; 3 (3) : e751
Publication History
Submission date: 11 Sep 2016
Revised on: 19 Sep 2016
Accepted on: 30 Sep 2016
Published online: 01 Oct 2016
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