MYC is a potent oncogene and its activation is frequently due by direct gene alteration, such as traslocation and amplification.Originally MYC chromosome translocation t(8;14)(q24;q32) has been considered an hallmark of  of Burkitt lymphoma, but later it have been identified in other mature B-cell neoplasms. Detection of translocations involving MYC at 8q24.1 in aggressive  B-cell lymphomas is important for diagnostic and prognostic purposes. Therefore, we analyze the genetic aberrations could be applied to a useful  Fluorescent In Situ Hybridization (FISH) approach in the diagnosis of these lymphomas.