High-Intensity Focused Ultrasound (HIFU) is a new non invasive technique that induce the ablation of tumors without damaging overlying and adjacent structures. This technique can be used clinically to treat solid tumours (both malignant and benign), including those of the prostate, liver, breast, kidney, bone and pancreas and may represent a valid alternative technique for the palliative treatment of this advanced cancer. The nonsurgical ablation methods are thought to be psychologically and cosmetically more satisfactory and more easily accepted by patients. HIFU therefore may play a key role in future clinical practice and may offer patients another choice when no other treatment available or when patient refused surgical operation.