Tumor disappearance on positron emission tomography computed tomography after S-1 treatment for postoperative local recurrence of gallbladder cancer

WCRJ 2023; 10: e2686
DOI: 10.32113/wcrj_20239_2686

  Topic: Gastrointestinal cancer     Category:

Abstract

Objective: Gallbladder cancer (GBC) typically follows an aggressive course with the standard of care for advanced disease; complete responses are rarely encountered.
We report a case in which tumor disappearance on positron emission tomography computed tomography (PET-CT) was treated with S-1 as the second-line treatment for local recurrence of GBC after gemcitabine (GEM) plus cisplatin (CDDP) (GC) combination therapy.

Case Presentation: A 69-year-old woman was referred to our hospital with complaints of right hypochondrial pain. Based on ultrasound, CT, and magnetic resonance imaging (MRI) findings, we diagnosed patient with suspected GBC.

Results: We performed the resection of the gallbladder base, partial resection of the transverse colon, and partial resection of the stomach for GBC. At four months after the surgery, PET-CT showed local recurrence. First-line chemotherapy with GC therapy was initiated. After 9 courses, PET-CT showed increased local recurrence. We concluded that GC treatment was ineffective. Second-line chemotherapy with S-1 was initiated for two weeks, followed by a 7-day rest period. PET-CT in September 2019 showed the markedly reduction of the local recurrence, and PET-CT in October 2021 showed the complete disappearance of the local recurrence. At 20 months after the discontinuation of S-1, PET-CT showed the complete disappearance of the local recurrence.

Conclusions: Chemotherapy with S-1 can be managed safely and was demonstrated to be effective in treating the local recurrence of GBC recurrence.

To cite this article

Tumor disappearance on positron emission tomography computed tomography after S-1 treatment for postoperative local recurrence of gallbladder cancer

WCRJ 2023; 10: e2686
DOI: 10.32113/wcrj_20239_2686

Publication History

Submission date: 02 Aug 2023

Revised on: 28 Aug 2023

Accepted on: 25 Sep 2023

Published online: 27 Sep 2023