Objective: Ovarian cancer is the most dreadful gynecological malignancy among females worldwide, with worst prognosis and non-effectiveness of its screening markers yielding false negative cases. The aim of the present study was to investigate the clinicopathological and epidemiological profile of ovarian cancer patients in Kashmir ethnicity.

Patients and Methods: The present observational cross-sectional study was conducted on 50 ovarian cancer patients who reported to the Department of General Surgery and Medical Oncology, SKIMS, Srinagar, from 2017 to 2019 and on 50 healthy female volunteers as age-matched controls. The clinicopathological and epidemiological profiles of the ovarian cancer patients were compared with those of normal controls. A detailed description of clinico-pathological, epidemiological, and etiological data was obtained from the in-patient record and questionnaire method and analyzed by Student's t-test to estimate statistically significant differences between cases and controls. The blood samples were assessed for CA-125 levels. p ≥ 0.05 differences were considered statistically significant.

Results: Of the 50 ovarian cancer patients, the most affected (48%) age group was 44–59 years. The majority (64%) of the patients belonged to stages III and IV of the disease. Abdominal distension and pelvic pain were the most frequent symptoms observed in 46% and 44% of cases, respectively. Using Pearson’s correlation coefficient, we observed a significant negative correlation of risk of ovarian cancer with menarcheal age and a highly significant positive correlation with menopausal age, age at marriage, BMI, and CA125 in ovarian cancer patients.

Conclusions: Most of the patients presented in an advanced stage of the disease and had CA125 levels of 500 U/ml. Awareness must be raised among women regarding the symptoms, warning signs, and risk factors of ovarian cancer because doing so will facilitate the early diagnosis of the disease.