Objective: The subtype distribution and clinical profile of Non‑Hodgkin’s Lymphoma (NHL) show a wide variation in the different geographical locations. There is paucity of data regarding this from Western India. This study was aimed to evaluate the clinical spectrum and distribution of NHL subtypes at a tertiary care hospital of Western India.

Patients and Methods: This prospective observational study was conducted over a period of 2 years among 178 NHL patients of all ages. Clinical evaluation and investigations including histopathological examination and immunohistochemistry of involved tissue, bone marrow examination, and other relevant tests were performed. Cases were categorized according to World Health Organization classification of tumours of lymphoid tissues (2017).

Results: There was a male preponderance (66.3%), and the commonest age group affected was 41-50 years (24.1%). The predominant symptom was neck swelling (51.1%), and the commonest sign was lymphadenopathy (70.2%), cervical lymph nodes being the most commonly involved (51.1%). Extra‑nodal involvement was seen in 37.6% patients, the head‑and‑neck being the most commonly involved site (16.3%). Majority of the NHLs were B-cell lymphomas (75.3%). Diffuse large B-cell lymphoma was the commonest subtype (36.5%) followed by peripheral T-cell lymphoma, not otherwise specified (10.7%). Pediatric NHL comprised of 11.2% of NHL, T-cell lymphoblastic lymphoma (T-LBL) being the commonest subtype (25%).

Conclusions: Our analysis confirmed findings of various previous studies from India with few key differences. Mantle cell lymphoma had marginally higher frequency than follicular lymphoma, and was the second commonest B-cell NHL. Burkitt’s lymphoma had lower frequency than T-LBL in children, and was the second commonest childhood NHL.