Objective: The aim of this systemic review and meta-analysis was to verify that whether knowledge about screening for cervical cancer related with usage of screening for cervical cancer among female in Ethiopia.

Previous studies on knowledge about screening for cervical cancer and usage of screening for cervical cancer indicated different findings. We include 12 studies in different regions of Ethiopia. We have done this study focusing on female’s usage of screening for cervical cancer

Materials and Methods: Electronic databases were searched from 2014 to 2019.on reference manager software reporting knowledge and usage of screening for cervical cancer. Data extraction and assessment were guided by PRISMA checklist. Observational studies and studies with Newcastle-Ottawa Scale score > 50% were included in the review. The combined adjusted Odds ratios (OR)) and 95% confidence intervals were calculated using random effect model

Results: Twelve observational studies involving 4704 participants, 1235 of which had usage of screening for cervical cancer, were included. The combined effect size (OR) for usage of screening for cervical cancer comparing female who know about screening for cervical cancer versus female who did not know about screening for cervical cancer was 1.16 (95%CI 0.28 to 4.77), p = 0.813, I² = 96.23%). There was significant = heterogeneity (Q = 291.78; p = 0.000; I² =9 6.23%%. No publication bias was observed (Egger’s test: p = 0.693, Begg’s test: p = 0.131). 47.16% (2218) women who know cervical cancer screening service 11.41% (537) engaged to use screening for cervical cancer. The proportion of utilization of screening for cervical cancer among female aged >20 years was 18.22% in 6 of the 12 studies. The overall proportion of screening usage for cervical cancer was 24.21% and 28.08% for those having knowledge of screening for cervical cancer and not having knowledge screening for cervical cancer, respectively.

Conclusions: Knowledge of screening for cervical cancer is not associated with usage of screening for cervical cancer. The association between age and usage of screening for cervical cancer should be explored further.