Objective: Breast cancer is the most common cancer among women worldwide. Women often use cosmetics every day. This study aimed to investigate the association between cosmetic products and developing breast cancer.

Patients and Methods: In a retrospective case-control study, 235 patients with breast cancer and 174 healthy women completed a valid questionnaire regarding the usage of cosmetic products (i.e., oxidant, hair color, tattoo, nail polish, lipstick, sunscreen, eye shadow, mascara, cream powder, and deodorant).

Results: The results showed that among different cosmetic products, only use of sunscreen had a protective effect on developing breast cancer (Odds ratio = 0.79, confidence interval = 0.67- 0.93, p-value = 0.006). In addition, the history of chronic disease had a protective effect on developing breast cancer (Odds ratio = 0.28, confidence interval = 0.15- 0.52, p-value < 0.001).

Conclusions: Use of oxidant, hair color, tattoo, nail polish, lipstick, eye shadow, mascara, cream powder, and deodorant were not associated with the risk of developing breast cancer. Use of sunscreen had a protective effect on developing breast cancer. According to the current study, cosmetic products may not increase the risk of breast cancer.