Objective: Testicular cancer is the most common cancer among male, which occurs between 15-44 years. It is essential to know the incidence, mortality, and risk factors of this disease for proper health planning and effective interventions to reduce its incidence. Therefore, the present study aimed to investigate the incidence and mortality of testicular cancer and its risk factors worldwide.

Materials and Methods: The present study reviewed published English studies by searching the databases namely PubMed, Google Scholar and Web of Science until the 2018. The search strategy included the keywords of “Testicular cancer”, “Epidemiology”, “Incidence”, “Mortality “, “Risk factors”, and “the world”. We investigated studies on the incidence, mortality and risk factors of testicular cancer.

Results: The incidence of testicular cancer was much lower in Asian, African and Central American countries than European one. The age-standardized incidence rate (ASIR) of testicular cancer was 1.5 per 100,000 people in the world. The highest incidence rate was observed in Europe (7.2-8.7) and the lowest incidence in Africa (0.3-0.6) and Asia (0.4-1.7). The incidence of testicular cancer has increasing trend in Europe and the United States.

Conclusions: The highest incidence of this disease was observed in Europe, but the lowest one was in Asia and Africa. Due to the growing incidence of this disease worldwide and the difference in disease trend among populations, further studies on epidemiological characteristics is needed to better understanding of its related risk factors.