In this issue, we highlight the most relevant discussion presented by speakers in the International Conference on theme Cancer and Pollution titled “Terra dei Fuochi, the starting point” which is held on July 7^th, 2018 in Caserta, Italy. The expert faculty has presented the current reports from literature in the fields of newest genomic test suitable in clinical practice for detoxification and pollution. The purpose of the diet treatment and medical prevention was to promote the rebalancing of nutritional minerals, in order to increase the cellular capacity to defend against xenobiotics known to be hazardous. The speakers confirmed the hypothesis that promoting detoxification by changing lifestyle, diet, is the main way to influence the cellular physiology and the intestinal flora (microbiota). In addition, prevention programs by specific diagnostic tests, is necessary for early detect neoplasia, and chronic disease.