Summary – Over the past years, the importance of the multidisciplinary approach to chronic pain, through a direct involvement of professionals from all branches of medicine who are confronted daily with pain patients, has emerged. Advances in pain management, have been achieved thought pre-clinical and clinical studies conducted by researchers and clinicians. The treatments normally used for managing pain usually lack of efficacy, thus new strategies have been developed so far. To date new researches have been focused on: a) the pre-operatory analgesia; b) the illicit and pain; c) cancer pain management; d) the application of nanotechnologies in treatment of chronic pain. Here, we reported the most relevant discussion presented by speakers in the conference “Personalized medicine in the VII Higher Education Course in Pain Management: “ Acute and Chronic Pain, from research to the clinic” held in Capri (11-13) October 2017 (Figure 1).